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naloxone mor antagonist  (Cayman Chemical)

 
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    Cayman Chemical naloxone mor antagonist
    Naloxone Mor Antagonist, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/naloxone mor antagonist/product/Cayman Chemical
    Average 90 stars, based on 1 article reviews
    naloxone mor antagonist - by Bioz Stars, 2026-02
    90/100 stars

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    selective mor antagonist naloxone  (Selleck Chemicals)
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    The effect of <t>MOR</t> <t>antagonist</t> <t>naloxone</t> on activations of PDGFRβ and microglia. ( A ) The %MPE in rats receiving naloxone 30 minutes before morphine administration were higher than those in morphine-tolerant rats from day 5 to 7. * P <0.05, *** P <0.001, vs Morphine+DMSO rats. ( B, C ) Pretreatment with naloxone inhibited the phosphorylation of PDGFRβ ( B ) and the increased expression of Iba1 ( C ) induced by morphine measured by Western blots. * P <0.05, ** P <0.01, vs NS+DMSO rats; # P <0.05, vs Morphine+DMSO rats. Values represent mean±SEM. n=6 in each group. Abbreviations: NS, normal saline; DMSO, dimethyl sulfoxide; %MPE, the percentage of maximal possible antinociceptive effect.
    Selective Mor Antagonist Naloxone, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/selective mor antagonist naloxone/product/Selleck Chemicals
    Average 90 stars, based on 1 article reviews
    selective mor antagonist naloxone - by Bioz Stars, 2026-02
    90/100 stars
    		  Buy from Supplier
    mor antagonist naloxone  (Selleck Chemicals)
    90
    Selleck Chemicals mor antagonist naloxone
    The effect of <t>MOR</t> <t>antagonist</t> <t>naloxone</t> on activations of PDGFRβ and microglia. ( A ) The %MPE in rats receiving naloxone 30 minutes before morphine administration were higher than those in morphine-tolerant rats from day 5 to 7. * P <0.05, *** P <0.001, vs Morphine+DMSO rats. ( B, C ) Pretreatment with naloxone inhibited the phosphorylation of PDGFRβ ( B ) and the increased expression of Iba1 ( C ) induced by morphine measured by Western blots. * P <0.05, ** P <0.01, vs NS+DMSO rats; # P <0.05, vs Morphine+DMSO rats. Values represent mean±SEM. n=6 in each group. Abbreviations: NS, normal saline; DMSO, dimethyl sulfoxide; %MPE, the percentage of maximal possible antinociceptive effect.
    Mor Antagonist Naloxone, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mor antagonist naloxone/product/Selleck Chemicals
    Average 90 stars, based on 1 article reviews
    mor antagonist naloxone - by Bioz Stars, 2026-02
    90/100 stars
    		  Buy from Supplier
    naloxone mor antagonist  (Cayman Chemical)
    90
    Cayman Chemical naloxone mor antagonist
    The effect of <t>MOR</t> <t>antagonist</t> <t>naloxone</t> on activations of PDGFRβ and microglia. ( A ) The %MPE in rats receiving naloxone 30 minutes before morphine administration were higher than those in morphine-tolerant rats from day 5 to 7. * P <0.05, *** P <0.001, vs Morphine+DMSO rats. ( B, C ) Pretreatment with naloxone inhibited the phosphorylation of PDGFRβ ( B ) and the increased expression of Iba1 ( C ) induced by morphine measured by Western blots. * P <0.05, ** P <0.01, vs NS+DMSO rats; # P <0.05, vs Morphine+DMSO rats. Values represent mean±SEM. n=6 in each group. Abbreviations: NS, normal saline; DMSO, dimethyl sulfoxide; %MPE, the percentage of maximal possible antinociceptive effect.
    Naloxone Mor Antagonist, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/naloxone mor antagonist/product/Cayman Chemical
    Average 90 stars, based on 1 article reviews
    naloxone mor antagonist - by Bioz Stars, 2026-02
    90/100 stars
    		  Buy from Supplier

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    The effect of MOR antagonist naloxone on activations of PDGFRβ and microglia. ( A ) The %MPE in rats receiving naloxone 30 minutes before morphine administration were higher than those in morphine-tolerant rats from day 5 to 7. * P <0.05, *** P <0.001, vs Morphine+DMSO rats. ( B, C ) Pretreatment with naloxone inhibited the phosphorylation of PDGFRβ ( B ) and the increased expression of Iba1 ( C ) induced by morphine measured by Western blots. * P <0.05, ** P <0.01, vs NS+DMSO rats; # P <0.05, vs Morphine+DMSO rats. Values represent mean±SEM. n=6 in each group. Abbreviations: NS, normal saline; DMSO, dimethyl sulfoxide; %MPE, the percentage of maximal possible antinociceptive effect.

    Journal: Journal of Pain Research

    Article Title: The Interaction Between Spinal PDGFRβ and μ Opioid Receptor in the Activation of Microglia in Morphine-Tolerant Rats

    doi: 10.2147/JPR.S255221

    Figure Lengend Snippet: The effect of MOR antagonist naloxone on activations of PDGFRβ and microglia. ( A ) The %MPE in rats receiving naloxone 30 minutes before morphine administration were higher than those in morphine-tolerant rats from day 5 to 7. * P <0.05, *** P <0.001, vs Morphine+DMSO rats. ( B, C ) Pretreatment with naloxone inhibited the phosphorylation of PDGFRβ ( B ) and the increased expression of Iba1 ( C ) induced by morphine measured by Western blots. * P <0.05, ** P <0.01, vs NS+DMSO rats; # P <0.05, vs Morphine+DMSO rats. Values represent mean±SEM. n=6 in each group. Abbreviations: NS, normal saline; DMSO, dimethyl sulfoxide; %MPE, the percentage of maximal possible antinociceptive effect.

    Article Snippet: Specific JNK MAPK inhibitor SP600125 (50 μg/10 μL, MedChem Express, China) and selective MOR antagonist naloxone (10 μg/10 μL, Selleckchem, USA) were dissolved in 20% dimethyl sulfoxide (DMSO, Sigma, USA), respectively.

    Techniques: Phospho-proteomics, Expressing, Western Blot, Saline

    Involvement of JNK signaling in MOR-induced PDGFRβ activation in morphine tolerance. ( A ) Pretreatment with naloxone 30 minutes before morphine administration inhibited the phosphorylation of JNK induced by morphine measured by Western blots. ** P <0.01, vs NS+DMSO rats; # P <0.05, vs Morphine+DMSO rats. ( B ) The %MPE in rats receiving JNK inhibitor SP600125 30 minutes before morphine administration were higher than those in morphine-tolerant rats from day 5 to 7. ** P <0.01, vs Morphine+DMSO rats. ( C–E ) Pretreatment with SP600125 reduced increased expressions of p-c-Jun ( C ), p-PDGFRβ ( D ), and Iba1 ( E ) induced by morphine measured by Western blots. * P <0.05, *** P <0.001, vs NS+DMSO rats; # P <0.05, ## P <0.01, vs Morphine+DMSO rats. ( F ) Pretreatment with imatinib had no influence on the increased expression of p-JNK induced by morphine measured by Western blots. ** P <0.01, vs NS+NS rats. Values represent mean±SEM. n=6 in each group. Abbreviations: NS, normal saline; DMSO, dimethyl sulfoxide; %MPE, the percentage of maximal possible antinociceptive effect.

    Journal: Journal of Pain Research

    Article Title: The Interaction Between Spinal PDGFRβ and μ Opioid Receptor in the Activation of Microglia in Morphine-Tolerant Rats

    doi: 10.2147/JPR.S255221

    Figure Lengend Snippet: Involvement of JNK signaling in MOR-induced PDGFRβ activation in morphine tolerance. ( A ) Pretreatment with naloxone 30 minutes before morphine administration inhibited the phosphorylation of JNK induced by morphine measured by Western blots. ** P <0.01, vs NS+DMSO rats; # P <0.05, vs Morphine+DMSO rats. ( B ) The %MPE in rats receiving JNK inhibitor SP600125 30 minutes before morphine administration were higher than those in morphine-tolerant rats from day 5 to 7. ** P <0.01, vs Morphine+DMSO rats. ( C–E ) Pretreatment with SP600125 reduced increased expressions of p-c-Jun ( C ), p-PDGFRβ ( D ), and Iba1 ( E ) induced by morphine measured by Western blots. * P <0.05, *** P <0.001, vs NS+DMSO rats; # P <0.05, ## P <0.01, vs Morphine+DMSO rats. ( F ) Pretreatment with imatinib had no influence on the increased expression of p-JNK induced by morphine measured by Western blots. ** P <0.01, vs NS+NS rats. Values represent mean±SEM. n=6 in each group. Abbreviations: NS, normal saline; DMSO, dimethyl sulfoxide; %MPE, the percentage of maximal possible antinociceptive effect.

    Article Snippet: Specific JNK MAPK inhibitor SP600125 (50 μg/10 μL, MedChem Express, China) and selective MOR antagonist naloxone (10 μg/10 μL, Selleckchem, USA) were dissolved in 20% dimethyl sulfoxide (DMSO, Sigma, USA), respectively.

    Techniques: Activation Assay, Phospho-proteomics, Western Blot, Expressing, Saline